cv

Research fellow and team leader in the Lee Cronin group at the University of Glasgow, working at the intersection of chemistry, automation, and AI. My work spans autonomous robotic experimentation, assembly-theory-based analysis of chemical complexity, and closed-loop laboratory systems integrating machine learning and large language models. I previously worked at Oxford and ETH Zurich, with training in organic and physical-organic chemistry and subsequent specialization in autonomous chemical systems. I have co-authored 29 publications listed on this website and hold one patent.

Basics

Name Michael Jirasek
Label Research Fellow and Team Leader in Autonomous Chemistry and AI-Driven Laboratory Automation
Email jirasekphd@gmail.com
Url https://www.michaeljirasek.com/
Summary Interdisciplinary chemist and research leader working at the interface of chemistry, robotics, and machine intelligence. I develop autonomous experimentation platforms and quantitative frameworks for chemical complexity and prebiological selection, with applications to origins-of-life research and closed-loop discovery.

Work

  • 2022.01 - Present

    Glasgow, United Kingdom

    Research Fellow and Team Leader
    University of Glasgow
    Leading a multidisciplinary team at the University of Glasgow developing autonomous chemistry platforms and assembly-theory-based methods for quantifying directed chemical exploration in prebiological systems.
    • Leading and managing a team of 9 researchers and graduate students, setting scientific direction and delivery milestones
    • Developing assembly-theory-derived metrics (including exploration ratio and ensemble assembly) for detecting directed chemical exploration
    • Designing open-ended peptide polymerization workflows (wet-dry cycling, CDI coupling, enzymatic catalysis) for origins-of-life studies
    • Integrating LLM-driven planning and literature extraction into automated laboratory workflows (ACRA platform)
    • Designing and building robotic chemistry hardware and control stacks (CAD, Arduino/ESP32 firmware, Python orchestration)
    • Building closed-loop systems combining reaction execution, automated sampling, low-field NMR, and iterative decision logic
    • Secured major research funding, including a $1.25M Alfred P. Sloan Foundation grant
  • 2021.01 - 2021.12

    Zurich, Switzerland

    Postdoctoral Researcher
    ETH Zurich
    Developed peptide-based supramolecular and porous materials, supervised MSc researchers, and contributed to project design and execution.
    • Synthesising modified amino acids and peptides using SSPS
    • Fabricating large supramolecular assemblies and confirming structure with TEM
    • Designing bio-compatible porous peptide-based metal-organic frameworks
    • Supervising master students and devising research objectives
  • 2020.01 - 2020.12

    Oxford, United Kingdom

    Postdoctoral Researcher
    University of Oxford
    Developed original MATLAB workflows for ring-current analysis from experimental NMR data and combined computational and experimental methods to study aromaticity in macrocycles.
    • Conceiving and developing original MATLAB software for predicting ring currents
    • Parsing NMR data from literature and interpreting using custom software
    • Computationally (DFT) and experimentally (NMR) studying aromaticity and ring-currents
  • 2010.09 - 2014.09

    Prague, Czech Republic

    Research Technician
    Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences
    Synthesized and characterized azonia-helicene compounds for bioactive screening and advanced chiroptical/crystallographic characterization workflows.
    • Synthesizing library of over 200 novel azonia-helicenes
    • Full characterization as potential drug candidates for telomerase activity
    • Screening for racemic conglomerate crystals by detecting second-harmonic generation and XRD
    • Organic compound synthesis for biological testing

Education

  • 2016.10 - 2020.02

    Oxford, United Kingdom

    PhD
    University of Oxford
    Physical Organic Chemistry
    • Graduate NMR course
    • Graduate Mass Spectrometry course
    • Communication Skills
  • 2014.09 - 2015.08

    Zurich, Switzerland

    Research Internship (Erasmus)
    ETH Zurich
    Organic Chemistry
    • Advanced Methods and Strategies in Synthesis
    • Organic Synthesis: Methods and Strategies
    • Computer-Assisted Drug Design
    • Functional Inorganics
  • 2013.09 - 2016.05

    Prague, Czech Republic

    MSc
    University of Chemistry and Technology
    Organic Chemistry
    • Organic Synthesis
    • Retrosynthesis
    • Reaction Mechanisms
    • Chemical Calculations
    • Organic Chemistry of Selected Elements
    • Coordination Chemistry
    • Metal-Organic Chemistry
    • Supramolecular Chemistry
    • Physical-Organic Chemistry
    • Organic Technology
  • 2010.09 - 2013.05

    Prague, Czech Republic

    BSc
    University of Chemistry and Technology
    Chemistry
    • Mathematics
    • Physics
    • Chemical Engineering
    • Physical Chemistry
    • Analytical Chemistry
    • General and Inorganic Chemistry
    • Organic Chemistry
    • Biochemistry

Skills

Research Leadership
Scientific strategy and program direction
Team leadership and mentorship
Cross-disciplinary project orchestration
Research planning and delivery governance
Autonomous Laboratory Systems
Closed-loop experimentation architecture
Robotic workflow design and integration
Analytical-feedback-driven decision systems
Scalable automation in chemical research
AI for Scientific Discovery
Machine learning in experimental science
LLM-enabled research workflows
Data-driven optimization of experiments
Computational support for autonomous discovery
Chemical and Spectroscopic Expertise
Synthetic and physical-organic chemistry
Multimodal spectroscopy and analytical interpretation
Mechanism-informed experiment design
High-complexity reaction-system investigation
Computational and Quantitative Methods
Computational chemistry workflows
Model-based interpretation of molecular systems
Quantitative complexity and selection analysis
Integration of simulation and experimental evidence

Languages

English
Fluent
Czech
Native
German
Basic

Interests

Chemistry Automation
Hardware design in CAD
Writing firmware for microcontrollers
Robotic platform development
Autonomous discovery systems
AI & Machine Learning
Large language models
Computer vision
Spectroscopic data interpretation
Closed-loop optimization

Awards

  • 2019
    Poster Prize
    18th International Symposium on Novel Aromatic Compounds (ISNA-18), Sapporo, Japan
  • 2019
    Poster Prize
    Artemis, Octopus and ULTRA User Meeting, Oxford
  • 2013
    Best Oral Contribution
    13th Interdisciplinary Session of Young Biologist, Biochemists and Chemists